background: hemophilia is the most frequent severe hereditary hemorrhagic disease due to deficiency of coagulation factors viii (hemophilia a) or ix (hemophilia b) in plasma. we aimed to identify patients with hemophilia in kermanshah, iran and assess the incidence of inhibitors in this population and its associated factors. methods: this study was conducted on patients with hemophilia a and b ...

Hemophilia is one of the most common inherited coagulation disorder; with almost half of the cases presents in the neonatal period with bleeding episodes specially post circumcision, although family history is present in about two third cases. Retroperitoneal hemorrhage is a very rare presentation of hemophilia and to the best of our knowledge has not described yet, as initial presentation of h...

  Background: Hemophilia is the most frequent severe hereditary hemorrhagic disease due to deficiency of coagulation factors VIII (Hemophilia A) or IX (Hemophilia B) in plasma. We aimed to identify patients with  hemophilia in Kermanshah, Iran and assess the incidence of inhibitors in this population and its associated factors. Methods: This study was conducted on patients with hemophilia...

Background: Hemophilia A and B are the most frequent congenital coagulation disorders. This study was conducted to determine the prevalence of hepatitis B, C and human immunodeficiency viruses among hemophilic patients in Hamadan, Iran. Patients and Methods: In this study, patients with hemophilia A and B treated in Hamedan Hemophilia Center, Hamedan, Iran, were screened for hepatitis B, C and...

Background: Hemophilia B is an X-linked recessive coagulation disorder caused by factor IX deficiency.  Analysis of factor IX gene polymorphisms is considered the best approach for prenatal diagnosis and carrier detection of hemophilia B where the identification of gene mutation is not easily possible. Objective: To study the frequency of three factor IX-linked restriction fragment length polym...

Hemophilia is a hemorrhagic disorder with sex-linked inherited pattern, characterized by an inability to amplify coagulation due deficiency in factor VIII (hemophilia A or classic) IX B). Sequencing of the genes involved hemophilia has provided description and record main mutations, as well correlation various degrees severity. Hemorrhagic manifestations are related levels circulating factor, m...

background: hemophilia a and b are the most frequent congenital coagulation disorders. this study was conducted to determine the prevalence of hepatitis b, c and human immunodeficiency viruses among hemophilic patients in hamadan, iran. patients and methods: in this study, patients with hemophilia a and b treated in hamedan hemophilia center, hamedan, iran, were screened for hepatitis b, c and ...

OBJECTIVE Hemophilia B is caused by coagulation defects in the factor IX gene located in Xq27.1 on the X chromosome. A wide range of mutations, showing extensive molecular heterogeneity, have been described in hemophilia B patients. Our study was aimed at genetic analysis and prenatal diagnosis of hemophilia B in order to further elucidate the pathogenesis of the hemophilia B pedigree in China....

conclusions the diagnostics and management of infections with hepatotropic viruses, particularly hbv, are neglected in hemophilic patients. all patients with coagulation disorders and a history of exposure to non-inactivated blood products should be screened for blood-borne infections. the prevalence of other potentially blood-borne viral infections exhibited a pattern similar to that observed ...